Solubility has been a major hurdle for many 𝐃𝐫𝐮𝐠 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 programs. Poor solubility of compounds can inherently impact on the quality of decision-making data which affects the following properties: ❌ Absorption ❌ Distribution ❌ Metabolism ❌ Excretion (ADME) ❌ Pharmacokinetic (PK)
Poor water solubility ultimately leads to low drug absorption and exposure. 💊💊💊
If your lead compound is suffering from low water solubility, Epichem can help. Epichem is highly experienced in improving water solubility through the preparation of various pro-drug derivatives including phosphates and sulfates.
